With average revenue of $1,874,514, Greenville businesses make twice as much as the average business in South Carolina. In addition, a large percentage of Greenville businesses have paid employees. It is home to large corporations, such as General Electric and Lockheed, but the city is also just as friendly to existing and growing small businesses. The city's Department of Economic Development offers small-business grants and loans , and Greenville Chamber of Commerce offers resources to help improve business conditions.

3. Myrtle Beach

The city, known for its soft sandy beaches and subtropical climate, attracts over 14 million visitors during the tourist season. Myrtle Beach caters to this influx with the most businesses per 100 people in state, which is four times the national average.